7 MLB Players Who Must Step Up in 2026 | Replacing Key Departures (2026)

Every team faces the harsh reality of losing star players, and the challenge of filling those voids can make or break a season. But here's the real question: Who steps up when the big names leave? It’s a pivotal moment that tests the depth and resilience of any roster. While some teams look outside for replacements, others turn to the talent already waiting in the wings—whether it’s a rising star, a seasoned veteran taking on a new role, or a player returning from injury. These transitions are where legends are made… or where teams falter. And this is the part most people miss: it’s not just about talent, but about timing, opportunity, and grit.

Below, we spotlight seven players who now find themselves at the center of their team’s rebuilding efforts. Their performances could redefine their careers—and their teams’ futures.

Marcelo Mayer, 3B, Red Sox
Boston’s infield dynamics shifted dramatically when Alex Bregman chose the Cubs over a Red Sox reunion. While acquiring Willson Contreras addressed one infield need, the spotlight now falls squarely on Mayer. Here’s where it gets controversial: Can a 23-year-old prospect truly fill the shoes of a proven star like Bregman? Mayer’s performance will determine whether Boston’s infield has been upgraded or merely reshuffled. With no other third baseman in sight, the pressure is on. But let’s ask: Is this the breakout moment Mayer needs, or is he being set up for unfair expectations?

Jacob Misiorowski, SP, Brewers
Trading ace Freddy Peralta to the Mets left a gaping hole in Milwaukee’s rotation. Enter Misiorowski, a 23-year-old flamethrower with elite velocity but an inconsistent rookie season. And this is the part most people miss: While his stuff is undeniable, the Brewers are banking on him to step into a frontline role alongside injury-prone veteran Brandon Woodruff. The question isn’t just whether Misiorowski can deliver—it’s whether he can handle the pressure of being the guy. Is this a recipe for success, or are the Brewers asking too much, too soon?

Andrew Painter, SP, Phillies
Once the top pitching prospect in baseball, Painter’s journey to the Majors has been anything but smooth. A UCL sprain and Tommy John surgery derailed his fast track, and his struggles last season raised doubts. But here’s where it gets controversial: With Ranger Suárez gone, the Phillies can no longer afford to wait. Painter, now MLB Pipeline’s No. 28 prospect, isn’t just a luxury—he’s a necessity. Can he finally live up to the hype, or has his window of opportunity closed? The 2026 season will tell, but one thing’s certain: the Phillies’ rotation needs him to shine.

Thought-provoking question for you: Which of these players do you think will rise to the occasion—and which ones might crumble under the pressure? Let’s debate in the comments!

7 MLB Players Who Must Step Up in 2026 | Replacing Key Departures (2026)
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